Kinetic isotope effects play a crucial role in understanding the mechanisms of chemical reactions. This article explores the different types of kinetic isotope effects and their impact on reaction rates.
What is the primary kinetic isotope effect?
The primary kinetic isotope effect tends to max out around 8 in practice.
How can kinetic isotope effects be measured?
Measuring the rate can help detect if the rate-determining step involves a proton transfer.
What is the secondary kinetic isotope effect?
The secondary kinetic isotope effect is observed in dissociative processes, where the attached atom in the transition state affects the reaction rate.
Are isotope substitution experiments necessary to measure kinetic isotope effects?
Isotope substitution experiments are not necessary to measure kinetic isotope effects in these reactions.
How can kinetic isotope effects be tracked in a mechanism?
Deuterium can be used to track the mechanistic pathway.
Kinetic isotope effects play a crucial role in understanding the mechanisms of chemical reactions. This article explores the different types of kinetic isotope effects and their impact on reaction rates.
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